Dextromethorphan/quinidine sulfate for pseudobulbar affect

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(NUEDEXTA ) for Pseudobulbar Affect

Pseudobulbar affect (PBA) is a dysfunction of emotional expression characterized by involuntary outbursts of crying or laughing disproportionate or unrelated to mood, occurring in patients with various underlying neurologic disorders. This review describes the clinical data supporting dextromethorphan (DM) hydrobromide combined with quinidine sulfate (Q) as treatment of PBA and briefly surveys ...

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Nuedexta for the Treatment of Pseudobulbar Affect

INTRODUCTION Pseudobulbar af fect (PBA), also known as emotional lability, labile affect, or emotional incontinence, refers to sudden outbursts of involuntary crying or laughing in patients with neurological disorders, even though there might not be any sad or humorous event to trigger those emotions.1,2 Patients may have episodes of laughing, crying, or both, without an apparent motivating sti...

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Recognizing and treating pseudobulbar affect.

Pseudobulbar affect, thought by many to be a relatively newly described condition, is in fact a very old one, described as early as the 19th century. It refers to those who experience inappropriate affect, disconnected from internal state, or mood, generally thought to be the result of an upper motor neuron injury or illness. One possible explanation for this condition's relative obscurity is t...

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Pseudobulbar affect: prevalence and management

Pseudobulbar affect (PBA) may occur in association with a variety of neurological diseases, and so may be encountered in the setting of amyotrophic lateral sclerosis, extrapyramidal and cerebellar disorders, multiple sclerosis, traumatic brain injury, Alzheimer's disease, stroke, and brain tumors. The psychological consequences and the impact on social interactions may be substantial. Although ...

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Pseudobulbar Affect in Multiple Sclerosis Patients.

The aim of the study was to determine the prevalence of pseudobulbar affect (PBA) in patients with multiple sclerosis (MS) and to analyze the link between PBA and patient age, sex, clinical course of MS, disease duration and degree of disability. The study was conducted on 79 MS patients that underwent inpatient rehabilitation at the Lipik Special Hospital for Medical Rehabilitation in the peri...

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ژورنال

عنوان ژورنال: Drugs of Today

سال: 2008

ISSN: 1699-3993

DOI: 10.1358/dot.2008.44.9.1258664